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Area of Technology:Life Sciences

Title of the Innovation: Process for Preparation of Nano-Curcumin based Formulation

Brief About Innovation

Nano-curcumin formulation (NCF) is a unique formulation containing nano curcumin and pyrroloquinolinequinine (PQQ), which supplements the brain and body to function and adapt in severe stressful conditions along with increasing work endurance. It has the potential to maintain general health at high altitudes especially cardiac health including several others.

 

Curcumin, a dietary pigment obtained from Curcuma longa, possesses tremendous therapeutic potential but has not been used as a drug of choice because of its poor bioavailability and rapid elimination. Studies were performed on the in-vivo animal model (Sprague Dawley rats) as well as on in-vitro models like Human Ventricular Cardiomyocytes (HVCM) and rodent cardiomyocytes (H9c2) showed anti-inflammatory and anti-apoptotic properties, maintains redox status thus improving overall health by modulating mitochondrial functioning, biogenesis and integrity. It also increases work endurance and cardiac function.

 

The toxicity analysis at GLP certified lab established NCF to be safe as per the pre-clinical requirements of CDSCO. The calculated (extrapolated) LD50 was more than 5000mg/kg BW. Thus, the proposed use of nano curcumin formulation as a potential therapeutic agent to maintain the general health at high altitudes especially cardiac health including several others.

 

Note*: This technology will be license through the bidding process only & the last date of bid submission is 15-11-2021.

For more details kindly show your interest.